HLA-DR53 molecules are associated with susceptibility to celiac disease and selectively bind gliadin-derived peptides

被引：0

作者：

Fabienne Clot

Carmen Gianfrani

Marie-Claude Babron

Faouzi Bouguerra

Scott Southwood

Martin F. Kagnoff

Riccardo Troncone

Selvaggia Percopo

Jean-François Eliaou

Françoise Clerget-Darpoux

Alessandro Sette

L. Greco

机构：

[1] Laboratoire de Génétique Moléculaire Humaine,

[2] Université de Versailles,undefined

[3] 25 avenue des Etats-Unis,undefined

[4] 78000 Versailles,undefined

[5] France,undefined

[6] Laboratoire d'Immunologie,undefined

[7] INSERM U. 291,undefined

[8] Hôpital Saint-Eloi,undefined

[9] 34295 Montpellier Cedex 5,undefined

[10] France,undefined

[11] Istituto di Scienze dell'Alimentazione,undefined

[12] CNR,undefined

[13] Via Roma 52,undefined

[14] 83100 Avellino,undefined

[15] Italy,undefined

[16] Department of Immunology,undefined

[17] Epimmune Inc.,undefined

[18] 6555 Nancy Ridge Dr,undefined

[19] San Diego,undefined

[20] CA 92121,undefined

[21] USA,undefined

[22] Unité d'Epidémiologie Génétique,undefined

[23] INSERM U. 155,undefined

[24] Château de Longchamp,undefined

[25] Bois de Boulogne,undefined

[26] 75016 Paris,undefined

[27] France,undefined

[28] Hôpital d'Enfants,undefined

[29] Service de Pédiatrie A and Institut National de la Santé Publique,undefined

[30] 5-7 Rue Khartoum,undefined

[31] 1007 Tunis,undefined

[32] Tunisia,undefined

[33] Department of Medicine,undefined

[34] University of California,undefined

[35] 0623D,undefined

[36] 9500 Gilman Dr. La Jolla,undefined

[37] San Diego,undefined

[38] CA 92093-0623,undefined

[39] USA,undefined

[40] Department of Pediatrics,undefined

[41] Federico II University,undefined

[42] Via S. Pansini 5,undefined

[43] 80131 Naples,undefined

[44] Italy e-mail: ydongre@cds.unina.it,undefined

[45] Tel.: +39-81-7463275,undefined

[46] Fax: +39-81-5469811,undefined

来源：

Immunogenetics | 1999年 / 49卷

关键词：

Key words Celiac disease; DR53; Binding; Gliadin peptides; HLA-association;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Celiac disease (CD) patients usually express a DQ2 heterodimer, whose chains DQα1*0501/DQβ1*0201, are encoded by the genes HLA-DQA1*0501 and DQB1*0201, respectively. Among the DQ2 carriers, the risk of developing disease was shown to correlate with the number of DQβ1*0201 chains encoded. Studying two separate cohorts of Italian and Tunisian patients, we now show a significant association of celiac disease with expression of either the DQ2 or DR53 heterodimers. The risk is maximal for individuals that carry both DQ2 and DR53 heterodimers. When twenty synthetic peptides overlapping most of A-gliadin sequence were tested for the binding to various purified DR molecules, it was found that DR53 molecules bind selectively and with high affinity (IC50<1 μM) to A-gliadin-derived peptides. These data suggest that both HLA DQ2 and DR53 molecules are associated with increased genetic risk for CD, and provide a possible biochemical basis for this complex association.

引用

页码：800 / 807

页数：7

共 23 条

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