Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

被引：0
|
作者：
Guk Young Ahn
Dong-Hyun Paik
Ki-Young Jeong
Seung-Woon Baek
Rae-Hyoung Kang
Eun Seong Lee
Sung-Wook Choi
机构：
[1] The Catholic University of Korea,Department of Biotechnology
来源：
Macromolecular Research | 2018年 / 26卷
关键词：
folic acid; ursolic acid; electrospraying; tumor therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies.
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页码：573 / 576
页数：3
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