Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells

被引：0
|
作者：
Arthur A. Hurwitz
Stephanie K. Watkins
机构：
[1] National Cancer Institute,Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program
来源：
Cancer Immunology, Immunotherapy | 2012年 / 61卷
关键词：
Tumor microenvironment; T cell; Tolerance; Suppression; CITIM 2011;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
引用
收藏
页码：289 / 293
页数：4
相关论文
共 50 条
  • [1] Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells
    Hurwitz, Arthur A.
    Watkins, Stephanie K.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (02) : 289 - 293
  • [2] Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion
    DeVito, Nicholas C.
    Plebanek, Michael P.
    Theivanthiran, Bala
    Hanks, Brent A.
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [3] Natural killer cell-mediated immune surveillance in cancer: Role of tumor microenvironment
    Saadh, Mohamed J.
    Rasulova, Irodakhon
    Khalil, Mohamed
    Farahim, Farha
    Sarbu, Ioan
    Ciongradi, Carmen Iulia
    Omar, Thabit Moath
    Alhili, Ahmed
    Jawad, Mahmood Jasem
    Hani, Thamer
    Ali, Talat
    Lakshmaiya, Natrayan
    PATHOLOGY RESEARCH AND PRACTICE, 2024, 254
  • [4] Role of regulatory T cell-mediated suppression
    Ullrich, N.
    Bopp, T.
    Stahl, H.
    Fauti, T.
    Mennerich, D.
    Schmitt, E.
    Schild, H.
    WIENER KLINISCHE WOCHENSCHRIFT, 2008, 120 : 172 - 172
  • [5] Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
    Steggerda, Susanne M.
    Bennett, Mark K.
    Chen, Jason
    Emberley, Ethan
    Huang, Tony
    Janes, Julie R.
    Li, Weiqun
    MacKinnon, Andrew L.
    Makkouk, Amani
    Marguier, Gisele
    Murray, Peter J.
    Neou, Silinda
    Pan, Alison
    Parlati, Francesco
    Rodriguez, Mirna L. M.
    Van de Velde, Lee-Ann
    Wang, Tracy
    Works, Melissa
    Zhang, Jing
    Zhang, Winter
    Gross, Matthew I.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [6] p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation
    Y Huang
    P Yu
    W Li
    G Ren
    A I Roberts
    W Cao
    X Zhang
    J Su
    X Chen
    Q Chen
    P Shou
    C Xu
    L Du
    L Lin
    N Xie
    L Zhang
    Y Wang
    Y Shi
    Oncogene, 2014, 33 : 3830 - 3838
  • [7] p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation
    Huang, Y.
    Yu, P.
    Li, W.
    Ren, G.
    Roberts, A. I.
    Cao, W.
    Zhang, X.
    Su, J.
    Chen, X.
    Chen, Q.
    Shou, P.
    Xu, C.
    Du, L.
    Lin, L.
    Xie, N.
    Zhang, L.
    Wang, Y.
    Shi, Y.
    ONCOGENE, 2014, 33 (29) : 3830 - 3838
  • [8] Nanoparticle interactions with immune cells dominate tumor retention and induce T cell-mediated tumor suppression in models of breast cancer
    Korangath, Preethi
    Barnett, James D.
    Sharma, Anirudh
    Henderson, Elizabeth T.
    Stewart, Jacqueline
    Yu, Shu-Han
    Kandala, Sri Kamal
    Yang, Chun-Ting
    Caserto, Julia S.
    Hedayati, Mohammad
    Armstrong, Todd D.
    Jaffee, Elizabeth
    Gruettner, Cordula
    Zhou, Xian C.
    Fu, Wei
    Hu, Chen
    Sukumar, Saraswati
    Simons, Brian W.
    Ivkov, Robert
    SCIENCE ADVANCES, 2020, 6 (13)
  • [9] Dendritic cells amplify T cell-mediated immune responses in the central nervous system
    Karman, Jozsef
    Chu, Hamlet H.
    Co, Dominic O.
    Seroogy, Christine M.
    Sandor, Matyas
    Fabry, Zsuzsanna
    JOURNAL OF IMMUNOLOGY, 2006, 177 (11): : 7750 - 7760
  • [10] T cell-mediated terminal maturation of dendritic cells
    Bergstresser, PR
    Kitajima, T
    Xu, S
    Ariizumi, K
    Takashima, A
    DENDRITIC CELLS IN FUNDAMENTAL AND CLINICAL IMMUNOLOGY, VOL 3, 1997, 417 : 65 - 69
12345