Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

被引:0
|
作者
Jonas Ecker
Ina Oehme
Ralph Mazitschek
Andrey Korshunov
Marcel Kool
Thomas Hielscher
Judit Kiss
Florian Selt
Carina Konrad
Marco Lodrini
Hedwig E Deubzer
Andreas von Deimling
Andreas E Kulozik
Stefan M Pfister
Olaf Witt
Till Milde
机构
[1] German Cancer Research Center (DKFZ),Clinical Cooperation Unit Pediatric Oncology (G340)
[2] Massachusetts General Hospital,Center for Systems Biology
[3] The Broad Institute of Harvard and MIT,Department of Neuropathology
[4] University Hospital Heidelberg,Clinical Cooperation Unit Neuropathology (G380)
[5] German Cancer Research Center (DKFZ),Division of Pediatric Neurooncology (B062)
[6] and German Cancer Consortium (DKTK),Division of Biostatistics (C060)
[7] German Cancer Research Center (DKFZ),Section of Pediatric Brain Tumors, Department of Pediatric Oncology, Hematology and Immunology
[8] Heidelberg,Department of Pediatric Hematology
[9] Germany,undefined
[10] and German Cancer Consortium (DKTK),undefined
[11] German Cancer Consortium (DKTK),undefined
[12] German Cancer Research Center (DKFZ),undefined
[13] University Hospital Heidelberg,undefined
[14] Oncology and Bone Marrow Transplantation,undefined
[15] Charité - University Medicine Berlin,undefined
关键词
Medulloblastoma; HDAC; HDAC inhibitor; HDAC2; MYC;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma
    Ecker, Jonas
    Oehme, Ina
    Mazitschek, Ralph
    Korshunov, Andrey
    Kool, Marcel
    Hielscher, Thomas
    Kiss, Judit
    Selt, Florian
    Konrad, Carina
    Lodrini, Marco
    Deubzer, Hedwig E.
    von Deimling, Andreas
    Kulozik, Andreas E.
    Pfister, Stefan M.
    Witt, Olaf
    Milde, Till
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2015, 3 : 22
  • [2] TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA
    Ecker, Jonas
    Oehme, Ina
    Selt, Florian
    Kool, Marcel
    Chavez, Lukas
    Hohloch, Juliane
    Valinciute, Gintvile
    van Tilburg, Cornelis M.
    Schnolzer, Martina
    Warnken, Uwe
    Wechsler-Reya, Robert
    Pfister, Stefan M.
    Witt, Olaf
    Milde, Till
    NEURO-ONCOLOGY, 2017, 19 : 41 - 42
  • [3] TARGETING AUTOPHAGY IN MYC AMPLIFIED MEDULLOBLASTOMA
    Bagchi, Aditi
    MacKeigan, Jeffery
    Cornelius, Albert
    PEDIATRIC BLOOD & CANCER, 2016, 63 : S70 - S70
  • [4] Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells
    Simon Zeuner
    Johanna Vollmer
    Romain Sigaud
    Sina Oppermann
    Heike Peterziel
    Dina ElHarouni
    Ina Oehme
    Olaf Witt
    Till Milde
    Jonas Ecker
    Journal of Neuro-Oncology, 2024, 166 : 99 - 112
  • [5] Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells
    Zeuner, Simon
    Vollmer, Johanna
    Sigaud, Romain
    Oppermann, Sina
    Peterziel, Heike
    Elharouni, Dina
    Oehme, Ina
    Witt, Olaf
    Milde, Till
    Ecker, Jonas
    JOURNAL OF NEURO-ONCOLOGY, 2024, 166 (01) : 99 - 112
  • [6] SYNERGISTIC DRUG COMBINATIONS FOR THE TREATMENT OF MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA
    Zeuner, Simon
    Vollmer, Johanna
    Peterziel, Heike
    Sigaud, Romain
    Oppermann, Sina
    ElHarouni, Dina
    Hielscher, Thomas
    Witt, Olaf
    Oehme, Ina
    Milde, Till
    Ecker, Jonas
    NEURO-ONCOLOGY, 2021, 23 : 7 - 8
  • [7] Synergistic interaction of HDACi and PLK1i in Group 3 MYC-amplified medulloblastoma
    Valinciute, Gintvile
    Ecker, Jonas
    Hielscher, Thomas
    Schmidt, Christin
    Remke, Marc
    Sigismondo, Gianluca
    Krijgsveld, Jeroen
    Pfister, Stefan M.
    Witt, Olaf
    Milde, Till
    CANCER RESEARCH, 2020, 80 (14) : 71 - 72
  • [8] Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1
    Zhao, Yang
    Li, Tiantian
    Tian, Shuaiwei
    Meng, Wei
    Sui, Yi
    Yang, Jian
    Wang, Baocheng
    Liang, Zhuangzhuang
    Zhao, Heng
    Han, Yipeng
    Tang, Yujie
    Zhang, Lei
    Ma, Jie
    CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 12473 - 12485
  • [9] Targeting protein synthesis pathways in MYC-amplified medulloblastoma
    Kumar, Devendra
    Kanchan, Ranjana
    Chaturvedi, Nagendra K.
    DISCOVER ONCOLOGY, 2025, 16 (01)
  • [10] TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA
    Delaidelli, Alberto
    Negri, Gian Luca
    Sidhu, Simran
    Cran, Jordan
    Remke, Marc
    Pfister, Stefan
    Kool, Marcel
    Taylor, Michael
    Maris, John
    Leprivier, Gabriel
    Sorensen, Poul
    NEURO-ONCOLOGY, 2018, 20 : 140 - 140