Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy

被引：0
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作者：
Ismail Sari
Omer Binicier
Merih Birlik
Servet Akar
Erkan Yilmaz
Aydanur Kargi
Fatos Onen
Nurullah Akkoc
机构：
[1] Dokuz Eylul University School of Medicine,Department of Internal Medicine, Division of Rheumatology
[2] Dokuz Eylul University School of Medicine,Department of Radiology
[3] Dokuz Eylul University School of Medicine,Department of Pathology
[4] Dokuz Eylul Universitesi Tip Fakultesi Ic hastaliklari ABD Immunoloji-Romatoloji,undefined
来源：
Rheumatology International | 2009年 / 29卷
关键词：
Tumor necrosis factor alpha inhibitors; Adverse effects;
D O I：
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摘要：
Tumor necrosis factor (TNF) alpha inhibitors are effective in the treatment of inflammatory rheumatic diseases. Despite their effectiveness, anti-TNF drugs have some drawbacks such as severe adverse effects including infections and possibly lymphoproliferative disorders. In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment. The clinical presentation was highly suggestive of malignancy and the patient underwent diagnostic mediastinoscopy with biopsy.
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