Two susceptibility loci identified for prostate cancer aggressiveness

被引：0

作者：

Sonja I. Berndt

Zhaoming Wang

Meredith Yeager

Michael C. Alavanja

Demetrius Albanes

Laufey Amundadottir

Gerald Andriole

Laura Beane Freeman

Daniele Campa

Geraldine Cancel-Tassin

Federico Canzian

Jean-Nicolas Cornu

Olivier Cussenot

W. Ryan Diver

Susan M. Gapstur

Henrik Grönberg

Christopher A. Haiman

Brian Henderson

Amy Hutchinson

David J. Hunter

Timothy J. Key

Suzanne Kolb

Stella Koutros

Peter Kraft

Loic Le Marchand

Sara Lindström

Mitchell J. Machiela

Elaine A. Ostrander

Elio Riboli

Fred Schumacher

Afshan Siddiq

Janet L. Stanford

Victoria L. Stevens

Ruth C. Travis

Konstantinos K. Tsilidis

Jarmo Virtamo

Stephanie Weinstein

Fredrik Wilkund

Jianfeng Xu

S. Lilly Zheng

Kai Yu

William Wheeler

Han Zhang

Joshua Sampson

Amanda Black

Kevin Jacobs

Robert N. Hoover

Margaret Tucker

Stephen J. Chanock

机构：

[1] National Cancer Institute,Division of Cancer Epidemiology and Genetics

[2] Cancer Genomics Research Laboratory,Division of Cancer Epidemiology and Genetics

[3] National Cancer Institute,Division of Urologic Surgery

[4] Leidos Biomedical Research Inc.,Division of Cancer Epidemiology

[5] Frederick National Laboratory for Cancer Research,Department of Medical Epidemiology and Biostatistics

[6] Washington University School of Medicine,Department of Preventative Medicine

[7] German Cancer Research Center (DKFZ),Department of Epidemiology

[8] CeRePP,Nuffield Department of Clinical Medicine

[9] Assistance Publique-Hôpitaux de Paris,Division of Public Health Sciences

[10] UPMC University Paris 6,Department of Epidemiology and Biostatistics

[11] Genomic Epidemiology Group,Department of Genomics of Common Disease

[12] German Cancer Research Center (DKFZ),Department of Epidemiology

[13] Epidemiology Research Program,Department of Hygiene and Epidemiology

[14] American Cancer Society,Department of Chronic Disease Prevention

[15] Karolinska Institute,Department of Epidemiology

[16] Keck School of Medicine,Department of Public Health Sciences

[17] University of Southern California/Norris Comprehensive Cancer Center,Department of Preventive Medicine

[18] Harvard School of Public Health,Division of Epidemiology, Department of Medicine

[19] Cancer Epidemiology Unit,Department of Urology

[20] University of Oxford,Department of Urology

[21] Fred Hutchinson Cancer Research Center,Department of Epidemiology and Biostatistics

[22] Epidemiology Program,Department of Surgery

[23] University of Hawaii Cancer Center,undefined

[24] National Human Genome Research Institute,undefined

[25] National Institutes of Health,undefined

[26] School of Public Health,undefined

[27] Imperial College,undefined

[28] School of Public Health,undefined

[29] Imperial College London,undefined

[30] School of Public Health,undefined

[31] University of Washington,undefined

[32] University of Ioannina School of Medicine,undefined

[33] National Institute for Health and Welfare,undefined

[34] Center for Cancer Genomics,undefined

[35] Wake Forest University School of Medicine,undefined

[36] Information Management Services Inc.,undefined

[37] University of Arizona College of Medicine and University of Arizona Cancer Center,undefined

[38] University of Texas M.D. Anderson Cancer Center,undefined

[39] Henry Ford Hospital,undefined

[40] Stony Brook University,undefined

[41] James Buchanan Brady Urological Institute,undefined

[42] Johns Hopkins Hospital and Medical Institution,undefined

[43] Vanderbilt Epidemiology Center,undefined

[44] Vanderbilt University School of Medicine,undefined

[45] University of Texas M.D. Anderson Cancer Center,undefined

[46] Korle Bu Teaching Hospital,undefined

[47] University of Ghana Medical School,undefined

[48] Westat,undefined

[49] Rockville,undefined

[50] School of Public Health,undefined

来源：

Nature Communications | / 6卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Most men diagnosed with prostate cancer will experience indolent disease; hence, discovering genetic variants that distinguish aggressive from nonaggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study of 12,518 prostate cancer cases, we identify two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49 × 10−9) and rs78943174 at 3q26.31 (NAALADL2, P=4.18 × 10−8). In a stratified case–control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85 × 10−5) with no association for nonaggressive prostate cancer compared with controls (P=0.57). The proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation.

引用

共 50 条

[1] Two susceptibility loci identified for prostate cancer aggressiveness
Berndt, Sonja I.
Wang, Zhaoming
Yeager, Meredith
Alavanja, Michael C.
Albanes, Demetrius
Amundadottir, Laufey
Andriole, Gerald
Freeman, Laura Beane
Campa, Daniele
Cancel-Tassin, Geraldine
Canzian, Federico
Cornu, Jean-Nicolas
Cussenot, Olivier
Diver, W. Ryan
Gapstur, Susan M.
Gronberg, Henrik
Haiman, Christopher A.
Henderson, Brian
Hutchinson, Amy
Hunter, David J.
Key, Timothy J.
Kolb, Suzanne
Koutros, Stella
Kraft, Peter
Le Marchand, Loic
Lindstroem, Sara
Machiela, Mitchell J.
Ostrander, Elaine A.
Riboli, Elio
Schumacher, Fred
Siddiq, Afshan
Stanford, Janet L.
Stevens, Victoria L.
Travis, Ruth C.
Tsilidis, Konstantinos K.
Virtamo, Jarmo
Weinstein, Stephanie
Wilkund, Fredrik
Xu, Jianfeng
Zheng, S. Lilly
Yu, Kai
Wheeler, William
Zhang, Han
Consortium, African Ancestry Prostate Canc G. W. A. S.
Sampson, Joshua
Black, Amanda
Jacobs, Kevin
Hoover, Robert N.
Tucker, Margaret
Chanock, Stephen J.
[J]. NATURE COMMUNICATIONS, 2015, 6
[2] Multiple newly identified loci associated with prostate cancer susceptibility
Eeles, Rosalind A.
Kote-Jarai, Zsofia
Giles, Graham G.
Al Olama, Ali Amin
Guy, Michelle
Jugurnauth, Sarah K.
Mulholland, Shani
Leongamornlert, Daniel A.
Edwards, Stephen M.
Morrison, Jonathan
Field, Helen I.
Southey, Melissa C.
Severi, Gianluca
Donovan, Jenny L.
Hamdy, Freddie C.
Dearnaley, David P.
Muir, Kenneth R.
Smith, Charmaine
Bagnato, Melisa
Ardern-Jones, Audrey T.
Hall, Amanda L.
O'Brien, Lynne T.
Gehr-Swain, Beatrice N.
Wilkinson, Rosemary A.
Cox, Angie
Lewis, Sarah
Brown, Paul M.
Jhavar, Sameer G.
Tymrakiewicz, Malgorzata
Lophatananon, Artitaya
Bryant, Sarah L.
Horwich, Alan
Huddart, Robert A.
Khoo, Vincent S.
Parker, Christopher C.
Woodhouse, Christopher J.
Thompson, Alan
Christmas, Tim
Ogden, Chris
Fisher, Cyril
Jamieson, Charles
Cooper, Colin S.
English, Dallas R.
Hopper, John L.
Neal, David E.
Easton, Douglas F.
[J]. NATURE GENETICS, 2008, 40 (03) : 316 - 321
[3] Multiple newly identified loci associated with prostate cancer susceptibility
Rosalind A Eeles
Zsofia Kote-Jarai
Graham G Giles
Ali Amin Al Olama
Michelle Guy
Sarah K Jugurnauth
Shani Mulholland
Daniel A Leongamornlert
Stephen M Edwards
Jonathan Morrison
Helen I Field
Melissa C Southey
Gianluca Severi
Jenny L Donovan
Freddie C Hamdy
David P Dearnaley
Kenneth R Muir
Charmaine Smith
Melisa Bagnato
Audrey T Ardern-Jones
Amanda L Hall
Lynne T O'Brien
Beatrice N Gehr-Swain
Rosemary A Wilkinson
Angie Cox
Sarah Lewis
Paul M Brown
Sameer G Jhavar
Malgorzata Tymrakiewicz
Artitaya Lophatananon
Sarah L Bryant
Alan Horwich
Robert A Huddart
Vincent S Khoo
Christopher C Parker
Christopher J Woodhouse
Alan Thompson
Tim Christmas
Chris Ogden
Cyril Fisher
Charles Jamieson
Colin S Cooper
Dallas R English
John L Hopper
David E Neal
Douglas F Easton
[J]. Nature Genetics, 2008, 40 : 316 - 321
[4] Prostate Cancer Susceptibility Loci Identified on Chromosome 12 in African Americans
Bonilla, Carolina
Hooker, Stanley
Mason, Tshela
Bock, Cathryn H.
Kittles, Rick A.
[J]. PLOS ONE, 2011, 6 (02):
[5] Two susceptibility loci identified for duodenal ulcers
Isobel Franks
[J]. Nature Reviews Gastroenterology & Hepatology, 2012, 9 (5) : 242 - 242
[6] Genomewide scan for prostate cancer-aggressiveness loci
Witte, JS
Goddard, KAB
Conti, DV
Elston, RC
Lin, J
Suarez, BK
Broman, KW
Burmester, JK
Weber, JL
Catalona, WJ
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (01) : 92 - 99
[7] New ovarian cancer susceptibility loci identified
Goode, Ellen L.
Chenevix-Trench, Georgia
Song, Honglin
Ramus, Susan J.
Bolton, Kelly
Vierkant, Robert A.
Berchuck, Andrew
Lawrenson, Kate
Palmieri, Rachel
Tsai, Ya-Yu
Sellers, Thomas A.
Gayther, Simon A.
Pharoah, Paul P. D.
[J]. CANCER RESEARCH, 2010, 70
[8] New susceptibility loci for testicular cancer identified
[J]. Nature Reviews Clinical Oncology, 2013, 10 (7) : 368 - 368
[9] Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry
Conti, David V.
Wang, Kan
Sheng, Xin
Bensen, Jeannette T.
Hazelett, Dennis J.
Cook, Michael B.
Ingles, Sue A.
Kittles, Rick A.
Strom, Sara S.
Rybicki, Benjamin A.
Nemesure, Barbara
Isaacs, William B.
Stanford, Janet L.
Zheng, Wei
Sanderson, Maureen
John, Esther M.
Park, Jong Y.
Xu, Jianfeng
Stevens, Victoria L.
Berndt, Sonja I.
Haiman, Christopher A.
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2017, 109 (08)
[10] Genome-wide scan of brothers: Replication and fine mapping of prostate cancer susceptibility and aggressiveness loci
Witte, JS
Suarez, BK
Thiel, B
Lin, J
Yu, A
Banerjee, TK
Burmester, JK
Casey, G
Catalona, WJ
[J]. PROSTATE, 2003, 57 (04): : 298 - 308

← 1 2 3 4 5 →