The pre-Bötzinger complex participates in generating the respiratory effects of thyroliberin

被引:3
|
作者
Inyushkin A.N. [3 ,4 ]
Merkulova N.A. [3 ,4 ]
Chepurnov S.A. [1 ]
机构
[1] W. G. Kerckhoff Institut, 61231 Parkstrasse 1, Bad Nauheim
[2] Department of Human and Animal Physiology, The State University, 1 Academician Pavlov Street, Samara
[3] M. V. Lomonosov Moscow State University, Vorob'ev Heights, Moscow
关键词
Pre-Bötzinger complex; Regulation of respiration and circulation; Thyroliberin;
D O I
10.1007/BF02465344
中图分类号
学科分类号
摘要
Experiments on anesthetized rats were performed to study the effects of microinjection of thyroliberin (10 fM-100 μM) into the area of the pre-Bötzinger complex on respiratory and circulatory parameters. Thyroliberin dose-dependently increased respiration frequency, with shortening of inspiration and expiration. Tidal volume and the amplitude of the integrated EMG recorded from the inspiratory muscles decreased after administration of concentrated solutions. Using this dosage method, thyroliberin had weak effects on systemic hemodynamics. The data suggest that structures located in the area of the pre-Bötzinger complex take part in generating the respiratory effects of thyroliberin. © 1999 Kluwer Academic/Plenum Publishers.
引用
收藏
页码:321 / 326
页数:5
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