Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum

被引：0
|
作者：
Dieter R. Klopfenstein
Elizabeth A. Holleran
Ronald D. Vale
机构：
[1] University of California San Francisco,Department of Cellular and Molecular Pharmacology
[2] University of California San Francisco,Howard Hughes Medical Institute
来源：
Journal of Muscle Research & Cell Motility | 2002年 / 23卷
关键词：
Biological Function; Eukaryotic Cell; Genetic Approach; Dictyostelium Discoideum; Membrane Organelle;
D O I：
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学科分类号：
摘要：
Movement of membrane cargoes and chromosomes is driven by kinesin and dynein motors in most eukaryotic cells. In this review, we describe the known kinesin and dynein genes in Dictyostelium. Dictyostelium primarily utilizes two conventional kinesins, an Unc104/KIF1 kinesin, and cytoplasmic dynein to transport membrane organelles within its cytoplasm. We describe how the biological functions of these motors has been dissected through a combination of biochemical to genetic approaches.
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页码：631 / 638
页数：7
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