Biodistribution of Osteotropic 177Lu-EDTMP – a Potential Radiopharmaceutical for Radionuclide Therapy of Bone Metastases

被引：0
|
作者：
Tishchenko V.K. [1 ]
Petriev V.M. [1 ,2 ]
Matveev A.V. [3 ]
Fedorova A.V. [1 ]
Kuzenkova K.A. [1 ]
机构：
[1] A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Radiology Center, Ministry of Health of the Russian Federation, 4 Koroleva St., Kaluga Oblast, Obninsk
[2] National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, Moscow
[3] F. M. Dostoevsky Omsk State University, 55 Prosp. Mira, Omsk
来源：
Pharmaceutical Chemistry Journal | 2022年 / 56卷 / 7期
关键词：
biodistribution; EDTMP; lutetium-177; N; N′; N′-ethylenediaminetetrakis(methylenephosphonic acid); nuclear medicine; osteotropic radiopharmaceuticals;
D O I：
10.1007/s11094-022-02744-6
中图分类号：
学科分类号：
摘要：
Phosphonates labeled with beta-emitting radionuclides are widely used in nuclear medicine for palliative therapy of bone metastases. This work was aimed at studying the biodistribution of a new osteotropic antitumor agent based on N,N,N′,N′-ethylenediaminetetrakis(methylenephosphonic acid) labeled with 177Lu (177Lu-EDTMP) in intact animals. The biodistribution in vivo in intact Wistar rats of free Lu in the form of 177LuCl3 was also investigated to assess the stability of 177Lu-EDTMP. It was found that 177Lu-EDTMP accumulated mainly in the skeleton (22.67 – 54.89% of the injected dose) with minimal uptake in other organs and tissues. The amount of 177LuCl3 in bone did not significantly differ from 177Lu-EDTMP uptake but the concentration of 177LuCl3 in soft organs was significantly higher (p < 0.05) as compared to that of 177Lu-EDTMP. The results indicated that further studies of 177Lu-EDTMP in clinical application for therapy of skeletal metastases had good prospects. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.
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页码：883 / 888
页数：5
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