Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation

被引：0
|
作者：
WenTao Yue
XiaoTing Zhao
LiNa Zhang
ZhiDong Liu
Li Ma
WenYun Jia
Zhe Qian
ChunYan Zhang
Yue Wang
XueHui Yang
ShaoFa Xu
机构：
[1] Capital Medical University,Department of Cellular Biology, Beijing Chest Hospital
[2] Capital Medical University,Department of Thoracic Surgery, Beijing Chest Hospital
来源：
Science China Life Sciences | 2010年 / 53卷
关键词：
CCNY; NSCLC; lentivirus RNAi; H1299;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.
引用
收藏
页码：511 / 516
页数：5
相关论文
共 50 条
  • [1] Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation
    YUE WenTao1
    2 Department of Thoracic Surgery
    [J]. Science China Life Sciences, 2010, 53 (04) : 511 - 516
  • [2] Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation
    Yue WenTao
    Zhao XiaoTing
    Zhang LiNa
    Liu ZhiDong
    Ma Li
    Jia WenYun
    Qian Zhe
    Zhang ChunYan
    Wang Yue
    Yang XueHui
    Xu ShaoFa
    [J]. SCIENCE CHINA-LIFE SCIENCES, 2010, 53 (04) : 511 - 516
  • [3] Overexpression of MYCN promotes proliferation of non-small cell lung cancer
    Liu, Kun
    Wang, Shuo
    Liu, Yifei
    Gu, Jun
    Gu, Shudong
    Xu, Zhen
    Zhang, Rui
    Wang, Zhiwen
    Ma, Huaci
    Chen, Yingying
    Ji, Lili
    [J]. TUMOR BIOLOGY, 2016, 37 (09) : 12855 - 12866
  • [4] The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer
    Liu, Yafang
    Zhan, Ping
    Zhou, Zejun
    Xing, Ze
    Zhu, Suhua
    Ma, Chenhui
    Li, Qian
    Zhu, Qingqing
    Miao, Yingying
    Zhang, Jianya
    Lv, Tangfeng
    Song, Yong
    [J]. JOURNAL OF THORACIC DISEASE, 2016, 8 (10) : 2911 - 2923
  • [5] Cell Cycle Protein Cyclin Y Is Associated With Human Non-Small-Cell Lung Cancer Proliferation and Tumorigenesis
    Yue, Wentao
    Zhao, Xiaoting
    Zhang, Lina
    Xu, Shaofa
    Liu, Zhidong
    Ma, Li
    Jia, Wenyun
    Qian, Zhe
    Zhang, Chunyan
    Wang, Yue
    Yang, Xuehui
    [J]. CLINICAL LUNG CANCER, 2011, 12 (01) : 43 - 50
  • [6] Prognostic significance of cyclin E overexpression in resected non-small cell lung cancer
    Fukuse, T
    Hirata, T
    Naiki, H
    Hitomi, S
    Wada, H
    [J]. CANCER RESEARCH, 2000, 60 (02) : 242 - 244
  • [7] DISC1 overexpression promotes non-small cell lung cancer cell proliferation
    Wang, Shuo
    Chen, Ying-Ying
    Li, Yu-Peng
    Gu, Jun
    Gu, Shu-Dong
    Shi, Hai
    Li, Xue-Song
    Lu, Xiao-Ning
    Li, Xiang
    Zhang, Shuang-Long
    Yu, Kang-Jun
    Liu, Kun
    Ji, Li-Li
    [J]. ONCOTARGET, 2017, 8 (39) : 65199 - 65210
  • [8] Overexpression of CRKL Correlates With Poor Prognosis and Cell Proliferation in Non-Small Cell Lung Cancer
    Wang, Yan
    Dong, Qian-ze
    Fu, Ling
    Stoecker, Maggie
    Wang, Endi
    Wang, En-Hua
    [J]. MOLECULAR CARCINOGENESIS, 2013, 52 (11) : 890 - 899
  • [9] Overexpression of γ-tubulin in non-small cell lung cancer
    Maounis, Nicoletta F.
    Draberova, Eduarda
    Mahera, Eleni
    Chorti, Maria
    Caracciolo, Valentina
    Sulimenko, Tetyana
    Riga, Dimitra
    Trakas, Nikolaos
    Emmanouilidou, Aphrodite
    Giordano, Antonio
    Draber, Pavel
    Katsetos, Christos D.
    [J]. HISTOLOGY AND HISTOPATHOLOGY, 2012, 27 (09) : 1183 - 1194
  • [10] Wntl overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients
    Nakashima, Takashi
    Liu, Dage
    Nakano, Jun
    Ishikawa, Shinya
    Yokomise, Hiroyasu
    Ueno, Masaki
    Kadota, Kyuichi
    Huang, Cheng-Long
    [J]. ONCOLOGY REPORTS, 2008, 19 (01) : 203 - 209
12345