Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy

被引：0
|
作者：
Karin Weissenborn
Georg Berding
Herbert Köstler
机构：
[1] Hochschule Hannover,Department of Neurology, Medizinische
[2] Medizinische,Department of Nuclear Medicine
[3] Hochschule Hannover,Department of Neuroradiology, Medizinische
[4] Hochschule Hannover,undefined
来源：
Metabolic Brain Disease | 2000年 / 15卷 / 3期
关键词：
D; dopamine receptor; dopamine transporter; hepatic encephalopathy;
D O I：
10.1007/BF02674526
中图分类号：
学科分类号：
摘要：
A patient suffering from liver cirrhosis presented with a bradykinetic-rigid syndrome suspected as Parkinson's disease. A detailed work-up of the case revealed hepatic encephalopathy as the cause of the neurological symptomatology. An alteration of striatal dopamine D2 receptor binding and dopamine re-uptake sites was demonstrated by123I-iodobenzamide (IBZM) and123I-ß-CIT single photon emission computed tomography (SPECT), respectively. It is suggested that the alteration of the dopamine re-uptake in cirrhotics may be the cause of an increased catabolism of dopamine in HE.
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页码：173 / 178
页数：5
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