Protein Powders for Encapsulation: A Comparison of Spray-Freeze Drying and Spray Drying of Darbepoetin Alfa

被引：0
|
作者：
Xichdao C. Nguyen
John D. Herberger
Paul A. Burke
机构：
[1] Amgen,Pharmaceutics and Drug Delivery
[2] Inc,Process Development
[3] Amgen,undefined
[4] Inc,undefined
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
NESP; spray lyophilization; protein stability; protein encapsulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To evaluate spray-freeze drying and spray drying processes for fabricating micron-sized particles of darbepoetin alfa (NESP, Aranesp®) with uniform size distribution and retention of protein integrity, requirements for encapsulation.
引用
收藏
页码：507 / 514
页数：7
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