Gonadal steroids and humoral immunity

被引：0
|
作者：
Sanaz Sakiani
Nancy J. Olsen
William J. Kovacs
机构：
[1] Diabetes,Division of Endocrinology
[2] and Metabolism,Division of Rheumatology
[3] The Pennsylvania State University College of Medicine,undefined
[4] Milton S. Hershey Medical Center,undefined
[5] 500 University Drive,undefined
[6] The Pennsylvania State University College of Medicine,undefined
[7] Milton S. Hershey Medical Center,undefined
[8] 500 University Drive,undefined
来源：
Nature Reviews Endocrinology | 2013年 / 9卷
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摘要：
Advances in understanding of B-lymphocyte maturation and immune tolerance are yielding new insight into the influence of gonadal steroids on the humoral immune system. Kovacs and colleagues examine how oestrogens and androgens directly and indirectly modulate B-lymphocyte development and function, focusing on B lymphopoiesis, elimination of autoreactive B-cell clones, and generation of high-affinity, class-switched, immunoglobulin-producing B cells.
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页码：56 / 62
页数：6
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