Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract

被引：0
|
作者：
J M Nicholls
M C W Chan
W Y Chan
H K Wong
C Y Cheung
D L W Kwong
M P Wong
W H Chui
L L M Poon
S W Tsao
Y Guan
J S M Peiris
机构：
[1] University of Hong Kong,Department of Pathology
[2] University of Hong Kong,Department of Microbiology
[3] University of Hong Kong,Department of Clinical Oncology
[4] Grantham Hospital,Department of Cardiothoracic Surgery
[5] Wong Chuk Hang Road,Department of Anatomy
[6] Wong Chuk Hang,undefined
[7] Aberdeen,undefined
[8] University of Hong Kong,undefined
[9] Pok Fu Lam Road,undefined
来源：
Nature Medicine | 2007年 / 13卷
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摘要：
Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.
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页码：147 / 149
页数：2
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