Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7

被引：0
|
作者：
Tomonori Nakamura
Naoko Kodama
Takuya Kumamoto
Yoshihiro Higuchi
Chaiyo Chaichantipyuth
Koichi Ueno
Tsutomu Ishikawa
Shingo Yano
机构：
[1] Chiba University,Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences
[2] Chiba University,Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences
[3] Chiba University,Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences
[4] Shiratori Pharmaceutical Co.,Material Development Laboratories
[5] Ltd.,Department of Pharmacognosy, Faculty of Pharmaceutical Sciences
[6] Chulalongkorn University,undefined
来源：
Journal of Natural Medicines | 2009年 / 63卷
关键词：
iNOS; Macrophage;
D O I：
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学科分类号：
摘要：
In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration-dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.
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页码：107 / 110
页数：3
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