Taste system is a perfect system to study degeneration and regeneration after nerve injury because the taste system is highly plastic and the regeneraton is robust. Besides, degeneration and regeneration can be easily measured since taste buds arise in discrete locations, and nerves that innervate them can be accurately quantified. Neurotrophins are a family of proteins that regulate neural surival, function, and plasticity after nerve injury. Recent studies have shown that neurotrophins play an important role in the developmental and mature taste system, indicating neurtrophin might also regulate taste system following gustatory nerve injury. This review will summarize how taste system degenerates and regenerates after gustatory nerve cut and conclude potential roles of neurotrophin in regulating the process.
机构:
Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22904 USAUniv Virginia, Dept Psychol, Charlottesville, VA 22904 USA
Guagliardo, Nick A.
West, Katie Nicole
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Med Coll Georgia, Inst Mol Med Dev Neurobiol, Augusta, GA 30912 USA
Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USAUniv Virginia, Dept Psychol, Charlottesville, VA 22904 USA
West, Katie Nicole
McCluskey, Lynnette P.
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Med Coll Georgia, Inst Mol Med Dev Neurobiol, Augusta, GA 30912 USA
Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USAUniv Virginia, Dept Psychol, Charlottesville, VA 22904 USA
McCluskey, Lynnette P.
Hill, David L.
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Univ Virginia, Dept Psychol, Charlottesville, VA 22904 USAUniv Virginia, Dept Psychol, Charlottesville, VA 22904 USA