Honokiol, magnolol, and a combination of both compounds improve glucose metabolism in high-fat diet-induced obese mice

Honokiol and magnolol are neolignans contained in the Chinese medicinal herb Magnolia officinalis that exert anti-tumor and anti-inflammatory effects. Both compounds have been reported to enhance glucose uptake. Little is known about effects when used in combination. The effects of honokiol, magnolol, and a combination of both compounds on lipid and glucose metabolism in highfat diet-induced obese mice were investigated, and underlying mechanisms were examined. All 3 treatments significantly (p<0.05) reduced plasma total cholesterol and glucose levels, and improved glucose tolerance, compared with controls. In addition, treatments increased mRNA expression of the peroxisome proliferator-activated receptor (PPAR)-γ, glucose transporter (GLUT)-4, and adiponectin genes in white adipose tissue (WAT). Both compounds individually and in combination significantly (p<0.05) increased Akt phosphorylation and GLUT4 protein expression in WAT compared to the control group. Honokiol and magnolol improve dyslipidemia and hyperglycemia and act synergistically when used in combination.