Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry

被引：0
|
作者：
Tomokazu Fukuda
Toshiyuki Kobayashi
Hideaki Yasui
Masahiro Tsutsumi
Yoichi Konishi
O. Hino
机构：
[1] Department of Experimental Pathology,
[2] Cancer Institute,undefined
[3] 1-37-1 Kami-ikebukuro,undefined
[4] Toshima-ku,undefined
[5] Tokyo 170-8455,undefined
[6] Japan e-mail: ohino@ims.u-tokyo.ac.jp Tel./Fax: +81-3-5394-3815,undefined
[7] Department of Oncological Pathology,undefined
[8] Cancer Center,undefined
[9] Nara Medical University,undefined
[10] 840 Shijo-cho,undefined
[11] Kashihara,undefined
[12] Nara 634-8521,undefined
[13] Japan,undefined
来源：
Virchows Archiv | 1999年 / 434卷
关键词：
Key words Tsc2 protein; Renal cell carcinoma; Eker rat; Tuberous sclerosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 Alterations in the rat tuberous sclerosis gene (Tsc2) are responsible for the hereditary renal carcinomas (RCs) of Eker rat. We examined protein distribution in various normal rat tissues and the Eker RCs by immunohistochemistry. Tsc2 protein is expressed in the mammary ducts, salivary glands, gastric glands, parathyroid, small and large intestine, ovary and uterus. Specific expression of Tsc2 protein is found in the B cells of pancreatic islets and in the smooth muscle of lung veins. Interestingly, in the RCs of Eker rat, Tsc2 protein was detectable with some variation in reactivity.
引用
收藏
页码：341 / 350
页数：9
相关论文
共 50 条
  • [1] Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry
    Fukuda, T
    Kobayashi, T
    Yasui, H
    Tsutsumi, M
    Konishi, Y
    Hino, O
    VIRCHOWS ARCHIV, 1999, 434 (04) : 341 - 350
  • [2] Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: Detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo
    Fukuda, T
    Kobayashi, T
    Momose, S
    Yasui, H
    Hino, O
    LABORATORY INVESTIGATION, 2000, 80 (09) : 1347 - 1359
  • [3] LYCOPENE IN THE PREVENTION OF RENAL CELL CANCER IN THE TSC2 MUTANT EKER RAT MODEL
    Cross, Brian
    Sahin, Kazim
    Sahin, Nurhan
    Ciccone, Karina
    Osunkoya, Adeboye
    Master, Viraj
    Harris, Wayne
    Carthon, Bradley
    Mohammad, Ramzi
    Bilir, Birdal
    Canter, Daniel
    Wertz, Karin
    Wu, Daqing
    Moreno, Carlos
    Walker, Cheryl
    Kucuk, Omer
    JOURNAL OF UROLOGY, 2012, 187 (04): : E63 - E63
  • [4] Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model
    Sahin, Kazim
    Cross, Brian
    Sahin, Nurhan
    Ciccone, Karina
    Suleiman, Shadeah
    Osunkoya, Adeboye O.
    Master, Viraj
    Harris, Wayne
    Carthon, Bradley
    Mohammad, Ramzi
    Bilir, Birdal
    Wertz, Karin
    Moreno, Carlos S.
    Walker, Cheryl L.
    Kucuk, Omer
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2015, 572 : 36 - 39
  • [5] Identification of cDNAs induced by the tumor suppressor Tsc2 gene using a conditional expression system in Tsc2 mutant (Eker) rat renal carcinoma cells
    Orimoto, K
    Tsuchiya, H
    Sakurai, J
    Nishizawa, M
    Hino, O
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 247 (03) : 728 - 733
  • [6] Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model
    Kikuchi, Y
    Sudo, A
    Mitani, H
    Hino, O
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2004, 24 (01) : 75 - 80
  • [7] Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells
    Orimoto, K
    Tsuchiya, H
    Kobayashi, T
    Matsuda, T
    Hino, O
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (01) : 70 - 75
  • [8] Second hit of Tsc2 gene in radiation induced renal tumors of Eker rat model
    Hino, O
    Mitani, H
    Sakaurai, J
    RADIATION AND HOMEOSTASIS, PROCEEDINGS, 2002, 1236 : 163 - 174
  • [9] Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat
    Fukuda, T
    Mitani, H
    Tsutsumi, M
    Konishi, Y
    Hino, O
    INTERNATIONAL JOURNAL OF ONCOLOGY, 1998, 13 (05) : 957 - 961
  • [10] MOLECULAR-GENETIC BASIS OF RENAL CARCINOGENESIS IN THE EKER RAT MODEL OF TUBEROUS SCLEROSIS (TSC2)
    HINO, O
    KOBAYASHI, E
    HIRAYAMA, Y
    KOBAYASHI, T
    KUBO, Y
    TSUCHIYA, H
    KIKUCHI, Y
    MITANI, H
    MOLECULAR CARCINOGENESIS, 1995, 14 (01) : 23 - 27
12345