Ceramide inhibits CCN2 expression in fibroblasts

被引：0

作者：

Laura Kennedy

Sunil Parapuram

Jill Greenspoon

Andrew Leask

机构：

[1] University of Western Ontario,CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Dental Sciences Building

来源：

Journal of Cell Communication and Signaling | 2008年 / 2卷

关键词：

CCN2; TGFβ;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Connective tissue growth factor (CTGF, CCN2) is induced in response to TGFβ in fibroblasts. In this report, we show that C2 ceramide reduced the ability of TGFβ to induce CCN2 protein, mRNA and promoter activity in fibroblasts. C2 ceramide reduced the ability of TGFβ to induce the generic Smad responsive promoter/reporter construct SBE-luciferase. These results suggest that C2 ceramide reduces the action of TGFβ in fibroblasts via Smad antagonism.

引用

页码：19 / 23

页数：4

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