Cholesterol metabolism in Huntington disease

被引：0
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作者：
Joanna M. Karasinska
Michael R. Hayden
机构：
[1] Centre for Molecular Medicine and Therapeutics,
[2] University of British Columbia,undefined
来源：
Nature Reviews Neurology | 2011年 / 7卷
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摘要：
Research has shown that Huntington disease, a progressive and fatal neurodegenerative disorder resulting from polyglutamine expansion in the huntingtin protein, is associated with changes in cellular cholesterol metabolism. Drawing on data from clinical and animal studies, Karasinska and Hayden discuss the roles of cholesterol in the CNS and describe the current state of knowledge of cholesterol dysregulation in Huntington disease.
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页码：561 / 572
页数：11
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