Idiopathic portal hypertension in a systemic sclerosis patient heterozygous for factor V Leiden mutation

被引：0

作者：

Masaru Ishii

Yoshinori Katada

机构：

[1] Department of Pharmacology,

[2] Graduate School of Medicine,undefined

[3] Osaka University,undefined

[4] Suita,undefined

[5] Osaka,undefined

[6] Japan,undefined

[7] Division of Allergy and Clinical Immunology,undefined

[8] National Osaka-minami Hospital,undefined

[9] Kawachinagano,undefined

[10] Osaka,undefined

[11] Japan,undefined

来源：

Rheumatology International | 2003年 / 23卷

关键词：

Coagulation factor V Idiopathic portal hypertension Leiden mutation Systemic sclerosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Here we present a rare case of systemic sclerosis (SSc) with idiopathic portal hypertension (IPH) having factor V Leiden mutation, a well-known genetic risk factor for various venous thromboses. A 53-year-old SSc patient showing huge esophageal varices and splenomegaly without liver cirrhosis was diagnosed with IPH. As heterozygous Leiden mutation was detected, some coagulation abnormality and resultant formation of microthrombi in the branches of portal vein were suggested as a cause of IPH in this case. This is the first report showing the possible association between Leiden mutation and one of the complications of SSc.

引用

页码：44 / 46

页数：2

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