Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH

被引：0
|
作者：
Josephine H. Li
Laura N. Brenner
Varinderpal Kaur
Katherine Figueroa
Philip Schroeder
Alicia Huerta-Chagoya
Miriam S. Udler
Aaron Leong
Josep M. Mercader
Jose C. Florez
机构：
[1] Massachusetts General Hospital,Center for Genomic Medicine
[2] Massachusetts General Hospital,Diabetes Unit
[3] Broad Institute of Harvard and MIT,Programs in Metabolism and Medical & Population Genetics
[4] Harvard Medical School,Division of Pulmonary and Critical Care Medicine
[5] Massachusetts General Hospital,Division of General Internal Medicine
[6] Massachusetts General Hospital,undefined
来源：
Diabetologia | 2023年 / 66卷
关键词：
Genetics; Genome-wide association study; Glipizide; Incretin; Metformin; Multi-ancestry; Pathophysiology; Pharmacogenetics; Sulfonylurea; Type 2 diabetes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1260 / 1272
页数：12
相关论文
共 50 条
  • [1] Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH
    Li, Josephine H.
    Brenner, Laura N.
    Kaur, Varinderpal
    Figueroa, Katherine
    Schroeder, Philip
    Huerta-Chagoya, Alicia
    Udler, Miriam S.
    Leong, Aaron
    Mercader, Josep M.
    Florez, Jose C.
    Magic Investigators
    Diab Prevent Program DPP Res Grp
    [J]. DIABETOLOGIA, 2023, 66 (07) : 1260 - 1272
  • [2] Genome-Wide Association Analysis Identifies Ancestry-Specific Genetic Variation Associated with Medication Response in the Study to Understand the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)
    Li, Josephine H.
    Kaur, Varinderpal
    Brenner, Laura
    Mercader, Josep M.
    Florez, Jose C.
    [J]. DIABETES, 2021, 70
  • [3] Genetic Risk Scores Predict Glycemic Traits and Response to Glipizide Treatment in the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)
    Li, Josephine H.
    Szczerbinski, Lukasz
    Kaur, Varinderpal
    Todd, Jennifer
    Florez, Jose C.
    [J]. DIABETES, 2019, 68
  • [4] International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
    Caroline M. Nievergelt
    Adam X. Maihofer
    Torsten Klengel
    Elizabeth G. Atkinson
    Chia-Yen Chen
    Karmel W. Choi
    Jonathan R. I. Coleman
    Shareefa Dalvie
    Laramie E. Duncan
    Joel Gelernter
    Daniel F. Levey
    Mark W. Logue
    Renato Polimanti
    Allison C. Provost
    Andrew Ratanatharathorn
    Murray B. Stein
    Katy Torres
    Allison E. Aiello
    Lynn M. Almli
    Ananda B. Amstadter
    Søren B. Andersen
    Ole A. Andreassen
    Paul A. Arbisi
    Allison E. Ashley-Koch
    S. Bryn Austin
    Esmina Avdibegovic
    Dragan Babić
    Marie Bækvad-Hansen
    Dewleen G. Baker
    Jean C. Beckham
    Laura J. Bierut
    Jonathan I. Bisson
    Marco P. Boks
    Elizabeth A. Bolger
    Anders D. Børglum
    Bekh Bradley
    Megan Brashear
    Gerome Breen
    Richard A. Bryant
    Angela C. Bustamante
    Jonas Bybjerg-Grauholm
    Joseph R. Calabrese
    José M. Caldas- de- Almeida
    Anders M. Dale
    Mark J. Daly
    Nikolaos P. Daskalakis
    Jürgen Deckert
    Douglas L. Delahanty
    Michelle F. Dennis
    Seth G. Disner
    [J]. Nature Communications, 10
  • [5] International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
    Nievergelt, Caroline M.
    Maihofer, Adam X.
    Klengel, Torsten
    Atkinson, Elizabeth G.
    Chen, Chia-Yen
    Choi, Karmel W.
    Coleman, Jonathan R., I
    Dalvie, Shareefa
    Duncan, Laramie E.
    Gelernter, Joel
    Levey, Daniel F.
    Logue, Mark W.
    Polimanti, Renato
    Provost, Allison C.
    Ratanatharathorn, Andrew
    Stein, Murray B.
    Torres, Katy
    Aiello, Allison E.
    Almli, Lynn M.
    Amstadter, Ananda B.
    Andersen, Sren B.
    Andreassen, Ole A.
    Arbisi, Paul A.
    Ashley-Koch, Allison E.
    Austin, S. Bryn
    Avdibegovic, Esmina
    Babic, Dragan
    Baekvad-Hansen, Marie
    Baker, Dewleen G.
    Beckham, Jean C.
    Bierut, Laura J.
    Bisson, Jonathan, I
    Boks, Marco P.
    Bolger, Elizabeth A.
    Brglum, Anders D.
    Bradley, Bekh
    Brashear, Megan
    Breen, Gerome
    Bryant, Richard A.
    Bustamante, Angela C.
    Bybjerg-Grauholm, Jonas
    Calabrese, Joseph R.
    Caldas-de-Almeida, Jose M.
    Dale, Anders M.
    Daly, Mark J.
    Daskalakis, Nikolaos P.
    Deckert, Juergen
    Delahanty, Douglas L.
    Dennis, Michelle F.
    Disner, Seth G.
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
  • [6] Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease
    Ge, Yi-Jun
    Chen, Shi-Dong
    Wu, Bang-Sheng
    Zhang, Ya-Ru
    Wang, Jun
    He, Xiao-Yu
    Liu, Wei-Shi
    Chen, Yi-Lin
    Ou, Ya-Nan
    Shen, Xue-Ning
    Huang, Yu-Yuan
    Gan, Yi-Han
    Yang, Liu
    Ma, Ling-Zhi
    Ma, Ya-Hui
    Chen, Ke-Liang
    Chen, Shu-Fen
    Cui, Mei
    Tan, Lan
    Dong, Qiang
    Zhao, Qian-Hua
    Wang, Yan-Jiang
    Jia, Jian-Ping
    Yu, Jin-Tai
    [J]. ALZHEIMERS & DEMENTIA, 2024,
  • [7] Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans
    Schick, Ursula M.
    Jain, Deepti
    Hodonsky, Chani J.
    Morrison, Jean V.
    Davis, James P.
    Brown, Lisa
    Sofer, Tamar
    Conomos, Matthew P.
    Schurmann, Claudia
    McHugh, Caitlin P.
    Nelson, Sarah C.
    Vadlamudi, Swarooparani
    Stilp, Adrienne
    Plantinga, Anna
    Baier, Leslie
    Bien, Stephanie A.
    Gogarten, Stephanie M.
    Laurie, Cecelia A.
    Taylor, Kent D.
    Liu, Yongmei
    Auer, Paul L.
    Franceschini, Nora
    Szpiro, Adam
    Rice, Ken
    Kerr, Kathleen F.
    Rotter, Jerome I.
    Hanson, Robert L.
    Papanicolaou, George
    Rich, Stephen S.
    Loos, Ruth J. F.
    Browning, Brian L.
    Browning, Sharon R.
    Weir, Bruce S.
    Laurie, Cathy C.
    Mohlke, Karen L.
    North, Kari E.
    Thornton, Timothy A.
    Reiner, Alex P.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2016, 98 (02) : 229 - 242
  • [8] Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans
    Gautam, Yadu
    Caldwell, Julie
    Kottyan, Leah
    Chehade, Mirna
    Dellon, Evan S.
    Rothenberg, Marc E.
    Mersha, Tesfaye B.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (05) : 1337 - 1350
  • [9] TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)
    Srinivasan, Shylaja
    Kaur, Varinderpal
    Chamarthi, Bindu
    Littleton, Katherine R.
    Chen, Ling
    Manning, Alisa K.
    Merino, Jordi
    Thomas, Melissa K.
    Hudson, Margo
    Goldfine, Allison
    Florez, Jose C.
    [J]. DIABETES CARE, 2018, 41 (03) : 554 - 561
  • [10] Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels
    Sarnowski, Chloe
    Ghanbari, Mohsen
    Bis, Joshua C.
    Logue, Mark
    Fornage, Myriam
    Mishra, Aniket
    Ahmad, Shahzad
    Beiser, Alexa S.
    Boerwinkle, Eric
    Bouteloup, Vincent
    Chouraki, Vincent
    Cupples, L. Adrienne
    Damotte, Vincent
    DeCarli, Charles S.
    DeStefano, Anita L.
    Djousse, Luc
    Fohner, Alison E.
    Franz, Carol E.
    Kautz, Tiffany F.
    Lambert, Jean-Charles
    Lyons, Michael J.
    Mosley, Thomas H.
    Mukamal, Kenneth J.
    Pase, Matthew P.
    Fernandez, Eliana C. Portilla
    Rissman, Robert A.
    Satizabal, Claudia L.
    Vasan, Ramachandran S.
    Yaqub, Amber
    Debette, Stephanie
    Dufouil, Carole
    Launer, Lenore J.
    Kremen, William S.
    Longstreth, William T.
    Ikram, M. Arfan
    Seshadri, Sudha
    [J]. COMMUNICATIONS BIOLOGY, 2022, 5 (01)
12345