Relative to other cities in Japan, Kyoto contains an outstanding agglomeration of historic buildings. These historic buildings are crucial for maintaining Kyoto’s irregular ranking as a historical city. However, several active faults occur near Kyoto that could cause severe seismic damage to the city. Thus, post-earthquake fire is one of the most threatening potential disasters that could destroy Kyoto’s invaluable historic buildings. Here, the post-earthquake fire safety of 2,131 historic buildings in the city of Kyoto was analyzed. This analysis was conducted by Monte Carlo simulation with a physics-based urban fire spread model that was formerly developed by the author. This scenario assumes the three following exclusive events that lead to the burn-down of historic buildings: (I) the ignition in the vicinity of the target historic building; (II) inadequate firefighting activity during the initial stage of the fire; and (III) the occurrence of widespread fire in urban areas following ignition. In general, the post-earthquake fire safety of designated and registered historic buildings was greater than that of undesignated and unregistered historic buildings. In addition, in the worst case scenario, 30% of the national treasures and important cultural properties would be damaged in the center of Kyoto city.