Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

被引：0
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作者：
Andrei Glinka
Wei Wu
Hajo Delius
A. Paula Monaghan
Claudia Blumenstock
Christof Niehrs
机构：
[1] Deutsches Krebsforschungszentrum,Division of Molecular Embryology
[2] Deutsches Krebsforschungszentrum,Division of Applied Tumorvirology
[3] Deutsches Krebsforschungszentrum,Division of Molecular Biology of the Cell I
来源：
Nature | 1998年 / 391卷
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摘要：
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.
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页码：357 / 362
页数：5
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