Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome

被引：0
|
作者：
H. Iwasa
M. Kurabayashi
R. Nagai
Y. Nakamura
T. Tanaka
机构：
[1] Laboratory of Molecular Medicine,
[2] Human Genome Center,undefined
[3] Institute of Medical Science,undefined
[4] University of Tokyo,undefined
[5] 4-6-1 Shirokanedai,undefined
[6] Minato-ku,undefined
[7] Tokyo 108-8639,undefined
[8] Japan Tel. +81-3-5449-5373; Fax +81-3-5449-5406 e-mail: toshitan@ims.u-tokyo.ac.jp,undefined
[9] Second Department of Internal Medicine,undefined
[10] Gunma University School of Medicine,undefined
[11] Gunma,undefined
[12] Japan,undefined
[13] Department of Cardiovascular Medicine,undefined
[14] Graduate School of Medicine,undefined
[15] University of Tokyo,undefined
[16] Tokyo,undefined
[17] Japan,undefined
来源：
Journal of Human Genetics | 2001年 / 46卷
关键词：
Key words Long QT syndrome; Single-nucleotide polymorphism; Japanese population; Cardiac potassium channel; β1-Adrenergic receptor; Vesicular monoamine transporter;
D O I：
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中图分类号：
学科分类号：
摘要：
We report here 20 single-nucleotide polymorphisms (SNPs), including 15 novel ones, in six genes that are considered to be candidates for long QT syndrome (LQTS): 2 SNPs in KCNB1, 3 in KCND3, 3 in KCNJ11, 7 in ABCC9, 3 in ADRB1, and 2 in SLC18A2. We also examined their allelic frequencies in a Japanese sample population of LQTS-affected and nonaffected individuals. These data will be useful for genetic association studies designed to investigate acquired arrhythmias.
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页码：158 / 162
页数：4
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