There is now accumulating evidence that the host immune system plays an important role in influencing response to treatment and prognosis in breast cancer. Immunotherapy with immune checkpoint inhibitors is a promising and rapidly growing field of interest in many solid tumours, including breast cancer. Trials to date have largely focused on metastatic triple-negative disease, a genomically unstable subtype of breast cancer that is believed to be the most immunogenic and following the development of treatment resistance, has limited treatment options and a particularly poor prognosis. Both checkpoint inhibitor monotherapy and combinations with chemotherapy are being investigated. In this review, we discuss the current evidence for PD-1/PD-L1 blockade in metastatic triple-negative breast cancer (TNBC), HER2+ breast cancer and ER+ disease, as well as the emerging evidence for use in the early-stage (neoadjuvant) setting. We also propose potential ways of improving responses to checkpoint blockade in breast cancer.
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Basu, Amrita
Ramamoorthi, Ganesan
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Ramamoorthi, Ganesan
Jia, Yongsheng
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Breast Oncol, Tianjin, Peoples R ChinaH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Jia, Yongsheng
Faughn, Jon
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Faughn, Jon
Wiener, Doris
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Wiener, Doris
Awshah, Sabrina
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Univ S Florida, Tampa, FL 33620 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Awshah, Sabrina
Kodumudi, Krithika
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Univ S Florida, Tampa, FL 33620 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
Kodumudi, Krithika
Czerniecki, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Breast Oncol, Tampa, FL 33612 USA
Univ S Florida, Tampa, FL 33620 USAH Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL 33612 USA
机构:
Vall Hebron Univ Hosp, Dept Med Oncol, Barcelona 08001, SpainMem Sloan Kettering Canc Ctr, Breast Canc Med Serv, New York, NY 10021 USA
Atzori, Francesco
Fornier, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Breast Canc Med Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Breast Canc Med Serv, New York, NY 10021 USA
机构:
Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA
Grimm, Lars J.
Mazurowski, Maciej A.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA
Duke Univ, Dept Elect & Comp Engn, Durham, NC USADuke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA