Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance

被引：0
|
作者：
Xiuyun Xuan
Chunxia Tian
Mengjie Zhao
Yanhong Sun
Changzheng Huang
机构：
[1] Huazhong University of Science and Technology,Department of Dermatology, Union Hospital, Tongji Medical College
[2] Hubei Provincial Hospital of TCM,Department of Cardiology
[3] Wuhan University,Department of Dermatology, Zhongnan Hospital
[4] Zhejiang University School of Medicine,Department of Dermatology, Second Affiliated Hospital
来源：
Cancer Cell International | / 21卷
关键词：
Mesenchymal stem cells; Cancer progression; Therapeutic resistance; Tumor microenvironment; Cytokine;
D O I：
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摘要：
Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.
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