No Association Between General Cognitive Ability and the A1 Allele of the D2 Dopamine Receptor Gene

被引：0

作者：

Stephen A. Petrill

Robert Plomin

Gerald E. McClearn

Deborah L. Smith

Sylvia Vignetti

Michael J. Chorney

Karen Chorney

Lee A. Thompson

Douglas K. Detterman

Camilla Benbow

David Lubinski

Joanna Daniels

Michael Owen

Peter McGuffin

机构：

[1] Institute of Psychiatry,Milton S. Hershey Medical Center

[2] The Pennsylvania State University,undefined

[3] The Pennsylvania State University,undefined

[4] Case Western Reserve University,undefined

[5] Iowa State University,undefined

[6] University of Wales College of Medicine,undefined

来源：

Behavior Genetics | 1997年 / 27卷

关键词：

Intelligence; D2 dopamine receptor; spatial ability; quantitative trait loci; association;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRJD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

引用

页码：29 / 31

页数：2

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