Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

被引：0

作者：

Yongfang Zhao

Daniel S. Terry

Lei Shi

Matthias Quick

Harel Weinstein

Scott C. Blanchard

Jonathan A. Javitch

机构：

[1] Center for Molecular Recognition,Department of Psychiatry

[2] Columbia University College of Physicians and Surgeons,Department of Pharmacology

[3] Columbia University College of Physicians and Surgeons,Division of Molecular Therapeutics

[4] Columbia University College of Physicians and Surgeons,Department of Physiology and Biophysics

[5] New York State Psychiatric Institute,undefined

[6] 1051 Riverside Drive,undefined

[7] Weill Medical College of Cornell University,undefined

[8] HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine,undefined

[9] Weill Cornell Medical College,undefined

[10] Cornell University,undefined

来源：

Nature | 2011年 / 474卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Neurotransmitters are removed from the synapse by neurotransmitter/Na+ symporters (NSSs) in a reuptake process driven by the Na+ gradient. Zhao et al. examined the coupling of substrate binding to structural transitions in the prokaryotic NSS homologue LeuT. Using single-molecule fluorescence resonance energy transfer, functional experiments and computational studies, they find that LeuT facilitates intracellular gate opening and substrate release at the intracellular face of the protein.

引用

页码：109 / 113

页数：4

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