Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

被引：0
|
作者：
M Früh
W Zhou
R Zhai
L Su
R S Heist
J C Wain
N S Nishioka
T J Lynch
F A Shepherd
D C Christiani
G Liu
机构：
[1] Medical Oncology,Department of Medicine
[2] Princess Margaret Hospital,Department of Environmental Health
[3] University of Toronto,Department of Medicine
[4] 610 University Avenue,Department of Surgery
[5] Harvard School of Public Health,Department of Medicine
[6] 665 Huntington Avenue,Department of Medicine
[7] Massachusetts General Hospital Cancer Center,undefined
[8] Harvard Medical School,undefined
[9] 665 Huntington Avenue,undefined
[10] Massachusetts General Hospital,undefined
[11] 10 Blossom Street,undefined
[12] Endoscopy Unit,undefined
[13] Massachusetts General Hospital,undefined
[14] 10 Blossom Street,undefined
[15] Pulmonary Unit,undefined
[16] Massachusetts General Hospital,undefined
[17] 10 Blossom Street,undefined
[18] Applied Molecular Oncology,undefined
[19] Ontario Cancer Institute,undefined
[20] 610 University Avenue,undefined
来源：
British Journal of Cancer | 2008年 / 98卷
关键词：
polymorphism; metalloproteinases; oesophageal cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1–0.7). Matrix metalloproteinases may modulate the EA–HP relationship.
引用
收藏
页码：689 / 692
页数：3
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