Amphiphilic Star-Shaped Calix[4]resorcinarene as Stationary Phase for Capillary Gas Chromatography

This work describes the separation performance of the amphiphilic star-shaped calix[4]resorcinarene (C4A-CL) as the stationary phase for capillary gas chromatography (GC). The statically coated C4A-CL capillary column exhibited medium polarity and high column efficiency of 3877 plates m−1 determined by naphthalene at 120 °C. Importantly, the C4A-CL column exhibited extremely high resolving capability for aliphatic analytes with varying polarity, including n-alkanes, esters, ketones, alcohols, and bromoalkanes. In addition, the C4A-CL column exhibited high selectivity and resolving capability for positional, structural and cis-/trans-isomers. Among them, the C4A-CL column displayed advantageous resolving capability over the commercial DB-17 column for aromatic amine isomers. Moreover, it was applied for the determination of isomer impurities in real samples, showing good potential in GC applications.