Salting-Out Thin-Layer Chromatography of Several Myorelaxants

被引：0
|
作者：
Mirjana Aleksić
Jadranka Odović
Dušanka M. Milojković-Opsenica
Živoslav Lj. Tešić
机构：
[1] University of Belgrade,Faculty of Pharmacy
[2] University of Belgrade,Faculty of Chemistry
来源：
JPC – Journal of Planar Chromatography – Modern TLC | 2003年 / 16卷
关键词：
Salting-out TLC; Myorelaxants; Cellulose; Alumina;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hRF values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the RM values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters RM0 and C0. Lipophilicity determined in this way correlated with calculated log P values.
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页码：144 / 146
页数：2
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