Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

被引：0
|
作者：
O. V. Yur’eva
V. I. Dubrovina
V. A. Potapov
M. V. Musalov
T. P. Starovoitova
T. A. Ivanova
T. T. Shkaruba
V. A. Yakimov
S. V. Balakhonov
机构：
[1] Irkutsk Antiplague Research Institute,A. E. Favorsky Irkutsk Institute of Chemistry
[2] Federal Service for Supervision of Consumer Rights Protection and Human Welfare,undefined
[3] Siberian Division of the Russian Academy of Science,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 169卷
关键词：
selenium-organic preparation; cAMP; cGMP; immunity; EV;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The experimental preparation reduced the cAMP/cGMP ratio, which indicated an increase in proliferative activity of cells of immunocompetent organs (thymus and spleen) in experimental animals. It was shown that 974zh intensified the immune response to Yersinia pestis EV thereby increasing the resistance to the plague agent.
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页码：40 / 42
页数：2
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