Feasibility of studying the association between intraoperative regional cerebral oxygen saturation and postoperative functional decline (ReFUNCTION): a pilot sub-study of NeuroVISION-Cardiac Surgery; [Est-il faisable d’étudier l’association entre la saturation peropératoire en oxygène cérébral régional et le déclin fonctionnel postopératoire (ReFUNCTION) ? Une sous-étude pilote de NeuroVISION-Cardiac Surgery]

被引：0

作者：

Spence J. ^{[1
,2
]}

Lamy A. ^{[2
,3
]}

Bosch J. ^{[2
,4
]}

Thabane L. ^{[2
,5
]}

Gagnon S. ^{[2
]}

Power P. ^{[2
]}

Browne A. ^{[2
]}

Murkin J. ^{[6
]}

Devereaux P.J. ^{[2
,7
]}

机构：

[1] Departments of Anesthesia and Critical Care and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton

[2] Population Health Research Institute, Hamilton, ON

[3] Departments of Surgery (Cardiac Surgery) and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton

[4] School of Rehabilitation Science, McMaster University, Hamilton

[5] Department of Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton

[6] Department of Anesthesiology and Perioperative Medicine, University of Western Ontario, London, ON

[7] Departments of Medicine and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton

来源：

Canadian Journal of Anesthesia/Journal canadien d'anesthésie | 2020年 / 67卷 / 11期

关键词：

cardiac surgery; functional outcomes; near-infrared spectroscopy; neurocognitive outcomes; pilot study;

D O I：

10.1007/s12630-020-01777-3

中图分类号：

学科分类号：

摘要：

Purpose: Function describes an individual’s ability to perform everyday activities. In the context of cardiac surgery, functional changes quantify the effect of surgery on one’s day-to-day life. Decreases in regional cerebral oxygen saturation (rScO2) measured using near-infrared spectroscopy (NIRS) has been associated with postoperative cognitive decline but its relationship with function has not been studied. We sought to determine the feasibility of conducting a large observational study examining the relationship between decreases in rScO2 during cardiac surgery and postoperative functional decline. Methods: We undertook a single-centre, pilot sub-study of the NeuroVISION-Cardiac Surgery pilot study, which included adults undergoing isolated coronary artery bypass grafting on cardiopulmonary bypass; all patients enrolled in NeuroVISION-Cardiac Surgery were included. Function was evaluated at baseline, 30 days, and three months using the Standardized Assessment of Global activities in the Elderly (SAGE) scale. Blinded NIRS monitors were affixed for the duration of surgery. Our feasibility outcomes were to recruit one patient per week, obtain complete NIRS data in ≥ 90%, obtain SAGE at all time-points in ≥ 90%, and determine the time required for NIRS data to be transcribed into case report forms. Results: 49/50 patients enrolled in NeuroVISION-Cardiac Surgery were recruited over 48 weeks (1.02 patients/week). Of the 49 included patients, 49 (100%) had complete NIRS data and 44 (90%) had complete SAGE data. The time required for NIRS data collection was a mean (standard deviation) of 5.5 (1.8) min per patient. Conclusion: This pilot study shows the feasibility of conducting a large observational study examining the relationship between decreases in cerebral saturation during cardiac surgery and postoperative functional decline. Trial registration: www.clinicaltrials.gov(NCT04241289); registered 27 January 2020. © 2020, Canadian Anesthesiologists' Society.

引用

页码：1497 / 1506

页数：9

共 1 条

[1] Feasibility of studying the association between intraoperative regional cerebral oxygen saturation and postoperative functional decline (ReFUNCTION): a pilot sub-study of NeuroVISION-Cardiac Surgery
Spence, Jessica
Lamy, Andre
Bosch, Jackie
Thabane, Lehana
Gagnon, Stephanie
Power, Patricia
Browne, Austin
Murkin, John
Devereaux, P. J.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 2020, 67 (11): : 1497 - 1506

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