A new fate mapping system reveals context-dependent random or clonal expansion of microglia

被引：0

作者：

Tuan Leng Tay

Dominic Mai

Jana Dautzenberg

Francisco Fernández-Klett

Gen Lin

Moumita Sagar

Anne Datta

Thomas Drougard

Alberto Stempfl

Ori Ardura-Fabregat

Anca Staszewski

Anje Margineanu

Lars M Sporbert

J Andrew Steinmetz

Steffen Pospisilik

Josef Jung

Dominic Priller

Olaf Grün

Marco Ronneberger

机构：

[1] Institute of Neuropathology,Department of Neuropsychiatry & Laboratory of Molecular Psychiatry

[2] Faculty of Medicine,Department of Genetics

[3] University of Freiburg,Department of Immunology

[4] Institute for Computer Science,undefined

[5] University of Freiburg,undefined

[6] Charité – Universitätsmedizin Berlin,undefined

[7] Genome Biology Unit,undefined

[8] European Molecular Biology Laboratory,undefined

[9] Max Planck Institute of Immunobiology and Epigenetics,undefined

[10] Center of Excellence for Fluorescent Bioanalytics,undefined

[11] University of Regensburg,undefined

[12] Advanced Light Microscopy Technology Platform,undefined

[13] Max Delbrück Center for Molecular Medicine,undefined

[14] Stanford University School of Medicine,undefined

[15] Stanford Genome Technology Center,undefined

[16] Weizmann Institute of Science,undefined

[17] Cluster of Excellence 'NeuroCure',undefined

[18] German Center for Neurodegenerative Diseases (DZNE) and Berlin Institute of Health (BIH),undefined

[19] BIOSS Centre for Biological Signalling Studies,undefined

[20] University of Freiburg,undefined

来源：

Nature Neuroscience | 2017年 / 20卷

关键词：

D O I：

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学科分类号：

摘要：

Microglia can expand and divide quickly in the context of CNS pathology, but little is known about the kinetics and clonality of microgliosis. Prinz and colleagues develop a new fate mapping system to monitor microglial dynamics. Microglial self-renewal is found to be a stochastic process under steady state conditions, whereas clonal expansion is observed during disease.

引用

页码：793 / 803

页数：10

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