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- [1] GBPs take AIM at Francisella[J]. NATURE IMMUNOLOGY, 2015, 16 (05) : 443 - 444Fitzgerald, Katherine A.Rathinam, Vijay A. K.
GBPs take AIM at Francisella
被引：0
|作者：
Katherine A Fitzgerald
Vijay A K Rathinam
机构：
[1] Katherine A. Fitzgerald is in the Program in Innate Immunity,Department of Medicine
[2] University of Massachusetts Medical School,Vijay A. K. Rathinam is in the Department of Immunology
[3] Worcester,undefined
[4] Massachusetts,undefined
[5] USA.,undefined
[6] University of Connecticut Health Center,undefined
[7] Farmington,undefined
[8] Connecticut,undefined
[9] USA.,undefined
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摘要：
Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of Francisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.
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页码：443 / 444
页数：1
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