Toxicology and pathology considerations for the design of juvenile animal studies

被引：1
|
作者：
Seely J.C. [1 ]
机构：
[1] Experimental Pathology Laboratories, Inc., Research Triangle Park, NC 27709
来源：
Lab Animal | 2008年 / 37卷 / 5期
关键词：
D O I：
10.1038/laban0508-206
中图分类号：
学科分类号：
摘要：
Although exposure to drugs or toxicants can affect children and adults very differently, many compounds lack specific safety information for children. Studies in juvenile animals can help researchers assess pediatric patients' potential response to certain chemicals. Juvenile studies are highly sensitive to animal age, sex and species and must be planned with care to prevent misinterpretation of experimental data. The author reviews considerations for the design of these studies, focusing on toxicological and pathological aspects.
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页码：206 / 209
页数：3
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