Extensive weight loss reduces glycan age by altering IgG N-glycosylation

被引：0
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作者：
Valentina L. Greto
Ana Cvetko
Tamara Štambuk
Niall J. Dempster
Domagoj Kifer
Helena Deriš
Ana Cindrić
Frano Vučković
Mario Falchi
Richard S. Gillies
Jeremy W. Tomlinson
Olga Gornik
Bruno Sgromo
Tim D. Spector
Cristina Menni
Alessandra Geremia
Carolina V. Arancibia-Cárcamo
Gordan Lauc
机构：
[1] University of Oxford,Translational Gastroenterology Unit and NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine
[2] University of Zagreb,Faculty of Pharmacy and Biochemistry
[3] Genos Glycoscience Research Laboratory,Oxford Centre for Diabetes and NIHR Oxford Biomedical Research Centre, Endocrinology and Metabolism, Radcliffe Department of Medicine
[4] University of Oxford,Department of Upper GI Surgery
[5] The Department of Twin Research,undefined
[6] King’s College London,undefined
[7] St Thomas’ Hospital,undefined
[8] Oxford University Hospitals,undefined
来源：
International Journal of Obesity | 2021年 / 45卷
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摘要：
Obesity is associated with inflammation-related agalactosylated and bisected IgG glycoforms.IgG bisected glycoforms decrease after low-calorie diet.IgG galactosylation and sialylation increase after bariatric surgery-induced weight loss.Progressive decrease of BMI is associated with increased IgG galactosylation, implying a reduction of biological age.
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页码：1521 / 1531
页数：10
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