Tolerability of breast ductal lavage in women from families at high genetic risk of breast cancer

被引:12
|
作者
Loud J.T. [1 ]
Beckjord E.B. [2 ]
Nichols K. [3 ]
Peters J. [1 ]
Giusti R. [4 ]
Greene M.H. [1 ]
机构
[1] Clinical Genetics Branch, National Cancer Institute, Rockville, MD
[2] Associate Behavioral and Social Sciences Researcher, RAND Corporation, Pittsuburgh, PA
[3] Westat, Inc, Rockville, MD
[4] Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD
基金
美国国家卫生研究院;
关键词
Breast Cancer; Mutation Carrier; Breast Cancer Survivor; Emotional Distress; Breast Cancer Screening;
D O I
10.1186/1472-6874-9-20
中图分类号
学科分类号
摘要
Background: Ductal lavage (DL) has been proposed as a minimally-invasive, well-tolerated tool for obtaining breast epithelial cells for cytological evaluation of breast cancer risk. We report DL tolerability in BRCA1/2 mutation-positive and -negative women from an IRB-approved research study. Methods: 165 BRCA1/2 mutation-positive, 26 mutation-negative and 3 mutation unknown women underwent mammography, breast MRI and DL. Psychological well-being and perceptions of pain were obtained before and after DL, and compared with pain experienced during other screening procedures. Results: The average anticipated and experienced discomfort rating for DL, 47 and 48 (0-100), were significantly higher (p < 0.01) than the anticipated and experienced discomfort of mammogram (38 and 34), MRI (36 and 25) or nipple aspiration (42 and 27). Women with greater pre-existing emotional distress experienced more DL-related discomfort than they anticipated. Women reporting DL-related pain as worse than expected were nearly three times more likely to refuse subsequent DL than those reporting it as the same or better than expected. Twenty-five percent of participants refused repeat DL at first annual follow-up. Conclusion: DL was anticipated to be and experienced as more uncomfortable than other procedures used in breast cancer screening. Higher underlying psychological distress was associated with decreased DL tolerability. © 2009 Loud et al; licensee BioMed Central Ltd.
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