Nuclear proteins: finding and binding target sites in chromatin

被引：0
|
作者：
Martin E. van Royen
Angelika Zotter
Shehu M. Ibrahim
Bart Geverts
Adriaan B. Houtsmuller
机构：
[1] Erasmus University Medical Center,Department of Pathology, Josephine Nefkens Institute
来源：
Chromosome Research | 2011年 / 19卷
关键词：
binding models; FRAP; high mobility; transient chromatin binding; diffusion; transcription; DNA repair;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fluorescent protein labelling, as well as impressive progress in live cell imaging have revolutionised the view on how essential nuclear functions like gene transcription regulation and DNA repair are organised. Here, we address questions like how DNA-interacting molecules find and bind their target sequences in the vast amount of DNA. In addition, we discuss methods that have been developed for quantitative analysis of data from fluorescence recovery after photobleaching experiments (FRAP).
引用
收藏
页码：83 / 98
页数：15
相关论文
共 50 条
  • [1] Nuclear proteins: finding and binding target sites in chromatin
    van Royen, Martin E.
    Zotter, Angelika
    Ibrahim, Shehu M.
    Geverts, Bart
    Houtsmuller, Adriaan B.
    CHROMOSOME RESEARCH, 2011, 19 (01) : 83 - 98
  • [2] Finding the target sites of RNA-binding proteins
    Li, Xiao
    Kazan, Hilal
    Lipshitz, Howard D.
    Morris, Quaid D.
    WILEY INTERDISCIPLINARY REVIEWS-RNA, 2014, 5 (01) : 111 - 130
  • [3] Global hinge sites of proteins as target sites for drug binding
    Zhang, Haotian
    Gur, Mert
    Bahar, Ivet
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 121 (49)
  • [4] Chromatin condensation modulates access and binding of nuclear proteins
    Martin, Robert M.
    Cardoso, M. Cristina
    FASEB JOURNAL, 2010, 24 (04): : 1066 - 1072
  • [5] Targeting GATA-1 to binding sites in nuclear chromatin
    West, Rachel
    Venkatesan, Priya
    Lowrey, Christopher
    BLOOD CELLS MOLECULES AND DISEASES, 2007, 38 (02) : 156 - 156
  • [6] Dynamics of finding and binding DNA target sites: A molecular perspective
    Levy, Yaakov
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [7] Studies on the α-crystallin target protein binding sites:: sequential binding with two target proteins
    Srinivas, V
    Datta, SA
    Ramakrishna, T
    Rao, CM
    MOLECULAR VISION, 2001, 7 (17): : 114 - 119
  • [8] The interaction between MYB proteins and their target DNA binding sites
    Prouse, Michael B.
    Campbell, Malcolm M.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2012, 1819 (01): : 67 - 77
  • [9] The role of nuclear proteins in the binding of anthracycline antibiotics, daunomycin and idarubicin, to chromatin
    Zahraie, Z.
    Rabbani, A.
    FEBS JOURNAL, 2006, 273 : 284 - 285
  • [10] Finding genetic target sites
    Burgess, Darren J.
    NATURE REVIEWS GENETICS, 2016, 17 (06) : 315 - 315
12345