Treatment of extensive bone defects requires autologous bone grafting or implantation of bone substitute materials. An attractive alternative has been to engineer fully viable, biological bone grafts in vitro by culturing osteogenic cells within three-dimensional scaffolds, under conditions supporting bone formation. Such grafts could be used for implantation, but also as physiologically relevant models in basic and translational studies of bone development, disease and drug discovery. A source of human cells that can be derived in large numbers from a small initial harvest and predictably differentiated into bone forming cells is critically important for engineering human bone grafts. We discuss the characteristics and limitations of various types of human embryonic and adult stem cells, and their utility for bone tissue engineering.
机构:
Columbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Marolt, Darja
Campos, Ivan Marcos
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Columbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Campos, Ivan Marcos
Bhumiratana, Sarindr
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Columbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Bhumiratana, Sarindr
Koren, Ana
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Columbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Blood Transfus Ctr Slovenia, SI-1000 Ljubljana, SloveniaColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Koren, Ana
Petridis, Petros
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Columbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Petridis, Petros
Zhang, Geping
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Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Zhang, Geping
Spitalnik, Patrice F.
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Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Spitalnik, Patrice F.
Grayson, Warren L.
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Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21231 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
Grayson, Warren L.
Vunjak-Novakovic, Gordana
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Columbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biomed Engn, New York, NY 10032 USA
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Steadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USASteadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USA
Gao, Xueqin
Ruzbarsky, Joseph J.
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Steadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USA
Steadman Clin, Aspen, CO 81611 USASteadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USA
Ruzbarsky, Joseph J.
Layne, Jonathan E.
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Steadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USASteadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USA
Layne, Jonathan E.
Xiao, Xiang
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Museum Fine Arts, Glassell Sch Art, Houston, TX 77006 USASteadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USA
Xiao, Xiang
Huard, Johnny
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Steadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USASteadman Philippon Res Inst, Linda & Mitch Hart Ctr Regenerat & Personalized Me, Vail, CO 81657 USA
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Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Inst Oral Biol, Coll Dent, Seoul 130701, South Korea
Kyung Hee Univ, Dept Prevent & Social Dent, Seoul 130701, South KoreaKyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Seong, Jeong Min
Kim, Byung-Chul
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Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Inst Oral Biol, Coll Dent, Seoul 130701, South KoreaKyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kim, Byung-Chul
Park, Jae-Hong
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Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Inst Oral Biol, Coll Dent, Seoul 130701, South KoreaKyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Park, Jae-Hong
Kwon, Il Keun
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Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Inst Oral Biol, Coll Dent, Seoul 130701, South KoreaKyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kwon, Il Keun
Mantalaris, Anathathios
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Univ London Imperial Coll Sci Technol & Med, Dept Chem Engn, London SW7 2AZ, EnglandKyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Mantalaris, Anathathios
Hwang, Yu-Shik
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Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Inst Oral Biol, Coll Dent, Seoul 130701, South KoreaKyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
机构:
Novadip Biosci, Rue Granbonpre 11, B-1435 Mont St Guibert, Belgium
Theracell Consulting, Lasne, BelgiumNovadip Biosci, Rue Granbonpre 11, B-1435 Mont St Guibert, Belgium