Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)

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作者
Antônio Talvane Torres de Oliveira
Céline Pinheiro
Adhemar Longatto-Filho
Maria Jose Brito
Olga Martinho
Delcio Matos
André Lopes Carvalho
Vinícius Lima Vazquez
Thiago Buosi Silva
Cristovam Scapulatempo
Sarhan Sydney Saad
Rui Manuel Reis
Fátima Baltazar
机构
[1] Pio XII Foundation,Departments of Digestive Surgery and Pathology and Centre for Researcher Support, Barretos Cancer Hospital
[2] University of Minho,Life and Health Sciences Research Institute (ICVS), School of Health Sciences
[3] ICVS/3B’s - PT Government Associate Laboratory,Laboratory of Medical Investigation (LIM) 14, Department of Pathology
[4] University of São Paulo School of Medicine,Department of Pathology
[5] Hospital Garcia de Orta,Department of Gastroenterology
[6] Medical School of the Federal University of São Paulo (UNIFESP),Molecular Oncology Research Center
[7] Barretos Cancer Hospital,undefined
关键词
Monocarboxylate transporters; CD147; Cancer metabolism; GISTs;
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摘要
Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher’s Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient’s overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.
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页码:171 / 178
页数:7
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