tudy on compatibility of imatinib mesylate with pharmaceutical excipients

被引：0
|
作者：
M. Łaszcz
B. Kosmacińska
K. Korczak
B. Śmigielska
M. Glice
W. Maruszak
A. Groman
H. Beczkowicz
Ł. Żelazko
机构：
[1] Pharmaceutical Research Institute,Quality Control and R&D Analytical Chemistry Department
[2] Pharmaceutical Research Institute,Pharmaceutical Department
来源：
Journal of Thermal Analysis and Calorimetry | 2007年 / 88卷
关键词：
compatibility; drug-excipient interactions; DSC; infrared spectroscopy; TG; X-ray powder diffraction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Differential scanning calorimetry and thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for the compatibility testing of imatinib mesylate, with following excipients: magnesium stearate, polyvinylpyrrolidone, microcrystalline cellulose. In order to maximize the probability of interactions 1:1 (by mass) drug: excipient binary mixtures were analysed and compared to individual components. Additionally an influence of storage at temperatures of 25 and 40°C on physico-chemical stability on drug – excipient binary mixtures was investigated.
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