Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder

被引：0
|
作者：
K Koido
T Traks
R Balõtšev
T Eller
A Must
S Koks
E Maron
I Tõru
J Shlik
V Vasar
E Vasar
机构：
[1] University of Tartu,Department of Physiology
[2] Centre of Excellence for Translational Medicine,Department of Psychiatry
[3] University of Tartu,Department of Neuropsychopharmacology and Molecular Imaging
[4] University of Tartu,Department of Psychiatry
[5] Imperial College London,undefined
[6] University of Ottawa,undefined
来源：
Translational Psychiatry | 2012年 / 2卷
关键词：
case–control association study; LSAMP; major depressive disorder; panic disorder; SNP;
D O I：
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学科分类号：
摘要：
The purpose of this case–control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed in 591 unrelated patients with the diagnoses of major depressive disorder (MDD) or panic disorder (PD) and in 384 healthy control subjects. The results showed a strong association between LSAMP SNPs and MDD, and a suggestive association between LSAMP SNPs and PD. This is the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.
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页码：e152 / e152
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