Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach

被引：0
|
作者：
Pascal Croiseau
Heather J Cordell
机构：
[1] Newcastle University,Institute of Human Genetics
[2] International Centre for Life,undefined
来源：
BMC Proceedings | / 3卷 / Suppl 7期
关键词：
Ridge Regression; Genetic Analysis Workshop; Group Lasso; North American Rheumatoid Arthritis Consortium; Lasso Estimator;
D O I：
10.1186/1753-6561-3-S7-S61
中图分类号：
学科分类号：
摘要：
We applied a penalized regression approach to single-nucleotide polymorphisms in regions on chromosomes 1, 6, and 9 of the North American Rheumatoid Arthritis Consortium data. Results were compared with a standard single-locus association test. Overall, the penalized regression approach did not appear to offer any advantage with respect to either detection or localization of disease-associated polymorphisms, compared with the single-locus approach.
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