Resolution of 2-nitroalcohols by Burkholderia cepacia lipase-catalyzed enantioselective acylation

被引：0
|
作者：
Na Li
Shi-Bin Hu
Gui-Ying Feng
机构：
[1] Northwest A&F University,Division of Microbiology, College of Life Sciences
[2] Northwest A&F University,Division of Environmental Engineering, College of Science
来源：
Biotechnology Letters | 2012年 / 34卷
关键词：
Enzymatic resolution; Lipase; 2-Nitroalcohols;
D O I：
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中图分类号：
学科分类号：
摘要：
Racemic 2-nitro-1-phenylethanol was resolved by via enantioselective transesterification catalyzed by Burkholderia cepacia lipase. The reaction afforded excellent E values (E > 200) and enantioselectivity (up to >99% enantiomeric excesses [ee]) of both remaining substrates and acetylated product. Moreover, the lipase displayed high enantioselectivity in the resolution of additional 2-nitroalcohols (E up to >200). This method provides an efficient alternative for obtaining enantiopure 2-nitroalcohols.
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页码：153 / 158
页数：5
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