Biological activity of a polypeptide modulator of TRPV1 receptor

被引：6

作者：

Dyachenko I.A. ^{[1
]}

Andreev Y.A. ^{[2
]}

Logashina Y.A. ^{[2
]}

Murashev A.N. ^{[1
]}

Grishin E.V. ^{[2
]}

机构：

[1] Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast

[2] Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow

来源：

Doklady Biological Sciences | 2015年 / 465卷 / 1期

基金：

俄罗斯科学基金会;

关键词：

Capsaicin; Transient Receptor Potential Vanilloid; Analgesic Activity; Cyanogen Bromide; Vanilloid Receptor;

D O I：

10.1134/S0012496615060034

中图分类号：

学科分类号：

摘要：

This paper presents data on the activity of a new APHC2 polypeptide modulator of TRPV1 receptors, which was isolated from the sea anemone Heteractis crispa. It has been shown that APHC2 has an analgesic activity, does not impair normal motor activity, and does not change body temperature of experimental animals, which has a great practical value for design of potent analgesics of a new generation. Further study of the characteristics of binding of the polypeptide to the TRPV1 receptor may show approaches to the development of other antagonists of this receptor that do not influence the body temperature. © 2015, Pleiades Publishing, Ltd.

引用

页码：279 / 281

页数：2

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