p16(INK4A)/MTS1/CDKN2 - The melanoma gene? [p16(INK4A)/MTS1/CDKN2 das'melanomgen'? Stand der forschung und ausblick]

被引：0
|
作者：
Bogenrieder T. [1 ,2 ]
Landthaler M. [1 ]
Stolz W. [1 ]
机构：
[1] Dermatologische Klin. und Poliklin., Universität Regensburg, D-93053 Regensburg
来源：
Der Hautarzt | 1998年 / 49卷 / 2期
关键词：
CDK-inhibitors; Cell cycle; Malignant melanoma; p16(INK4A); Tumor-suppressor gen;
D O I：
10.1007/s001050050706
中图分类号：
学科分类号：
摘要：
The gene of the cyclin-dependent kinase 4 (CDK4)-inhibitor p16(INK4A) (CDKN2/MTS1) has been proposed as a candidate for a tumor-suppressor gene located on chromosome 9p21, a frequently deleted region in a series of human cancers including malignant melanoma. An increasing and sometimes conflicting body of data has accumulated regarding the frequency of homozygous deletions and mutations as well as the importance of p16(INK4A) in malignant melanoma. The purpose of this review is therefore to summarize the current knowledge on p16(INK4A) and to discuss its biologic significance in the pathogenesis of melanocytic tumors.
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页码：91 / 100
页数：9
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