Liposome-Mediated Therapy of Intracranial Brain Tumors in a Rat Model

被引：0
|
作者：
Uma S. Sharma
Amarnath Sharma
Robert I. Chau
Robert M. Straubinger
机构：
[1] State University of New York,The Department of Pharmaceutics, University at Buffalo
[2] Eli Lilly and Co.,Department of Pharmaceutics
[3] State University of New York,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
brain tumor; liposomes; drug delivery; doxorubicin; confocal fluorescence microscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Malignant brain tumors represent a serious therapeutic challenge, and survival often is low. We investigated the delivery of doxorubicin (DXR) to rat brain tumors in situ vialiposomes, to test the hypothesis that intact liposomes undergo deposition in intracranial tumor through a compromised blood-tumor vasculature. Both therapeutic effect and intra-tumor drug carrier distribution were evaluated to identify variables in carrier-mediated delivery having impact on therapy.
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收藏
页码：992 / 998
页数：6
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