Age-related sarcopenia and its pathophysiological bases

被引：65
|
作者：
Ogawa S. [1 ]
Yakabe M. [1 ]
Akishita M. [1 ]
机构：
[1] Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo
来源：
Inflammation and Regeneration | / 36卷 / 1期
基金：
日本学术振兴会;
关键词：
Aging; Frailty; Hormone; Inflammation; Sarcopenia;
D O I：
10.1186/s41232-016-0022-5
中图分类号：
学科分类号：
摘要：
Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition and diagnostic criteria for sarcopenia have been outlined as consensus statements from several study groups, including usual gait speed, grip strength, and skeletal muscle mass. Whereas underlying mechanisms and pathophysiology of sarcopenia remains to be clarified, recent studies have suggested that chronic inflammatory status as well as lifestyle-related factors in older individuals might contribute to the process and progress of sarcopenia. © 2016 The Author(s).
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